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CELL DEATH

PD-L1 controls cancer pyroptosis

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Programmed death ligand-1 (PD-L1) is well known for its role as an immune checkpoint regulator, but little is known about its function in other cellular processes. A study now shows that in tumour cells PD-L1 mediates pyroptosis, an inflammatory form of cell death, by activating the expression of Gasdermine C, ultimately leading to tumour necrosis.

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Fig. 1: nPD-L1 mediates pyroptosis, leading to tumour necrosis.

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Authors and Affiliations

  1. Cancer Science Program, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

    María Teresa Blasco & Roger R. Gomis

  2. CIBERONC, Madrid, Spain

    Roger R. Gomis

  3. Universitat de Barcelona, Barcelona, Spain

    Roger R. Gomis

  4. ICREA, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

    Roger R. Gomis

Authors
  1. María Teresa Blasco
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  2. Roger R. Gomis
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Correspondence to Roger R. Gomis.

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The authors declare no competing interests.

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Blasco, M.T., Gomis, R.R. PD-L1 controls cancer pyroptosis. Nat Cell Biol 22, 1157–1159 (2020). https://doi.org/10.1038/s41556-020-00582-w

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