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MEMBRANE TRAFFICKING

Clock regulation of protein secretion

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The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.

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Fig. 1: The molecular clock drives circadian gene expression of clock-controlled genes.
Fig. 2: Clock control of the protein secretory pathway.

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Authors and Affiliations

  1. Center for Clinical Pharmacology, Washington University and St. Louis College of Pharmacy, St. Louis, MO, USA

    Thomas P. Burris

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  1. Thomas P. Burris
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Correspondence to Thomas P. Burris.

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Burris, T.P. Clock regulation of protein secretion. Nat Cell Biol 22, 1–3 (2020). https://doi.org/10.1038/s41556-019-0449-4

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