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Unraveling bone marrow architecture

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Different types of stromal cells in the bone marrow associate to form niches that support differentiating blood cells and ensure lifelong production of all major blood lineages. A study now combines single-cell and spatial transcriptomics with imaging to infer the cellular composition and spatial architecture of specific niches.

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Fig. 1: Scheme showing the experimental workflow used by Baccin, Al-Sabah, Velten et al. to dissect the cellular architecture of the bone marrow (BM) microenvironment.

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Authors and Affiliations

  1. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Medical center, Cincinnati, OH, USA

    Daniel Lucas & H. Leighton Grimes

  2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Daniel Lucas, Nathan Salomonis & H. Leighton Grimes

  3. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Nathan Salomonis

  4. Division of Immunobiology and Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    H. Leighton Grimes

Authors
  1. Daniel Lucas
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  2. Nathan Salomonis
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  3. H. Leighton Grimes
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Correspondence to H. Leighton Grimes.

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The authors declare no competing interests.

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Lucas, D., Salomonis, N. & Grimes, H.L. Unraveling bone marrow architecture. Nat Cell Biol 22, 5–6 (2020). https://doi.org/10.1038/s41556-019-0447-6

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