Cell identity is shaped by a complex interplay between transcription factors, enhancers and genome organisation. A study now reveals a dynamic role for the transcription factor KLF4 in directing gene regulatory interactions during pluripotent cell reprogramming, demonstrating that transcription factors can function as chromatin organisers.
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Rugg-Gunn, P.J. Transcription factors make the right contacts. Nat Cell Biol 21, 1173–1174 (2019). https://doi.org/10.1038/s41556-019-0399-x
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DOI: https://doi.org/10.1038/s41556-019-0399-x
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