Assembly of the mitotic spindle requires timely separation of the centrosomes. Their movement apart is driven by the plus-end-directed kinesin Eg5. A new study demonstrates that the kinesin KIFC3 provides an opposing microtubule-based cohesive force that modulates centrosome separation and ensures accurate chromosome segregation.
References
Prosser, S. L. & Pelletier, L. Nat. Rev. Mol. Cell Biol. 18, 187–201 (2017).
Conduit, P. T., Wainman, A. & Raff, J. W. Nat. Rev. Mol. Cell Biol. 16, 611–624 (2015).
Bahe, S., Stierhof, Y. D., Wilkinson, C. J., Leiss, F. & Nigg, E. A. J. Cell Biol. 171, 27–33 (2005).
Mayor, T., Stierhof, Y. D., Tanaka, K., Fry, A. M. & Nigg, E. A. J. Cell Biol. 151, 837–846 (2000).
Faragher, A. J. & Fry, A. M. Mol. Biol. Cell 14, 2876–2889 (2003).
Kapitein, L. C. et al. Nature 435, 114–118 (2005).
Hata, S. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0382-6 (2019).
Jean, C., Tollon, Y., Raynaud-Messina, B. & Wright, M. Eur. J. Cell Biol. 78, 549–560 (1999).
Panic, M., Hata, S., Neuner, A. & Schiebel, E. PLoS Genet. 11, e1005243 (2015).
Mazo, G., Soplop, N., Wang, W. J., Uryu, K. & Tsou, M. F. Dev. Cell 39, 424–437 (2016).
Decarreau, J. et al. Nat. Cell Biol. 19, 384–390 (2017).
Mardin, B. R. et al. Nat. Cell Biol. 12, 1166–1176 (2010).
Saunders, W., Lengyel, V. & Hoyt, M. A. Mol. Biol. Cell 8, 1025–1033 (1997).
Floriot, S. et al. Nat. Commun. 6, 6894 (2015).
Remo, A. et al. Mol. Cancer Res. 16, 1385–1395 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Morrison, C.G. KIFC3 directs a centrosome cohesive force. Nat Cell Biol 21, 1057–1059 (2019). https://doi.org/10.1038/s41556-019-0385-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-019-0385-3
- Springer Nature Limited