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Parkin inhibits necroptosis to prevent cancer

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Loss-of-function mutations in the ubiquitin ligase Parkin are a cause of Parkinson’s disease. Parkin also has tumour-suppressor activity, although how Parkin prevents cancer is unclear. Unexpectedly, Parkin is found to suppress cancer by inhibiting an inflammatory type of cell death called necroptosis.

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Fig. 1: Parkin inhibits necroptosis to prevent inflammation-induced cancer.

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Authors and Affiliations

  1. Cancer Research UK Beatson Institute, Glasgow, UK

    Kai Cao & Stephen W. G. Tait

  2. Institute of Cancer Sciences, University of Glasgow, Glasgow, UK

    Kai Cao & Stephen W. G. Tait

Authors
  1. Kai Cao
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  2. Stephen W. G. Tait
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Correspondence to Stephen W. G. Tait.

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The authors declare no competing interests.

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Cao, K., Tait, S.W.G. Parkin inhibits necroptosis to prevent cancer. Nat Cell Biol 21, 915–916 (2019). https://doi.org/10.1038/s41556-019-0350-1

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