Rag GTPases play a crucial role in mTORC1 activation by promoting its recruitment to the lysosomal surface in a nutrient-dependent manner. A study now identifies a family of lysosomal G-protein-coupled receptors as modulators of Rag GTPases localization and activation, adding one more component to the fast-growing mTOR regulatory network.
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Puertollano, R. GPCRs join the mTORC1 regulatory network. Nat Cell Biol 21, 538–539 (2019). https://doi.org/10.1038/s41556-019-0320-7
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DOI: https://doi.org/10.1038/s41556-019-0320-7
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