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Endothelial cells revealed as chondroclasts

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Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates blood vessel growth in bone and is supported by type H endothelial cells. These type H capillaries, in turn, release proteinases that promote cartilage degradation.

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Fig. 1: The supportive and destructive functions of type H endothelial cells.

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Authors and Affiliations

  1. Mount Sinai Bone Program, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Jameel Iqbal & Mone Zaidi

  2. Department of Pathology, James J. Peters VA Medical Center, Bronx, NY, USA

    Jameel Iqbal

Authors
  1. Jameel Iqbal
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  2. Mone Zaidi
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Correspondence to Mone Zaidi.

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The authors declare no competing interests.

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Iqbal, J., Zaidi, M. Endothelial cells revealed as chondroclasts. Nat Cell Biol 21, 417–419 (2019). https://doi.org/10.1038/s41556-019-0306-5

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