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IRE1α maintains HSC stemness under ER-stress

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Healthy and malignant haematopoietic stem cells (HSCs) must overcome a variety of cell intrinsic and extrinsic stresses to maintain their functionality. Now, IRE1α –XBP1 signalling is shown to protect HSCs and to promote survival of, and confer competitive advantages to, NRAS-mutated pre-leukaemic cells.

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Fig. 1: IRE1α signalling in cell fate determination during ER stress.

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Authors and Affiliations

  1. Department of Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    Marina Scheller-Wendorff & Carsten Müller-Tidow

Authors
  1. Marina Scheller-Wendorff
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  2. Carsten Müller-Tidow
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Correspondence to Carsten Müller-Tidow.

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Competing interests

C. Müller-Tidow's leukaemia research in Investigator Initiated Trials is supported by Pfizer, Janssen and Daiichi Sankyo. Clinical trials and other research within the Department of Medicine, Hematology, Oncology and Rheumatology are supported by multiple pharmaceutical companies.

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Scheller-Wendorff, M., Müller-Tidow, C. IRE1α maintains HSC stemness under ER-stress. Nat Cell Biol 21, 297–298 (2019). https://doi.org/10.1038/s41556-019-0295-4

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