Maintaining plasma membrane tension is important for eukaryotic cells. How altered membrane tension is sensed and relayed to downstream factors, such as the target of rapamyin complex 2 (TORC2), is poorly understood. Reorganization of a signalling lipid into discrete membrane domains is now shown to inactivate TORC2 in yeast.
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Ebner, M., Haucke, V. Mechanical signals regulate TORC2 activity. Nat Cell Biol 20, 994–995 (2018). https://doi.org/10.1038/s41556-018-0181-5
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DOI: https://doi.org/10.1038/s41556-018-0181-5
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