The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.
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Pérez-Palacios, R., Bourc’his, D. A single-cell chromatin map of human embryos. Nat Cell Biol 20, 742–744 (2018). https://doi.org/10.1038/s41556-018-0134-z
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DOI: https://doi.org/10.1038/s41556-018-0134-z
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