AMPK is a key metabolic sensor promoting cellular energy homeostasis under low-nutrient conditions and other stresses. However, its role in cancer is context-dependent and not fully understood. A study now shows that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.
This is a preview of subscription content, log in via an institution to check access.
References
Liang, J. & Mills, J. B. Cancer Res. 73, 2929–2935 (2013).
Chhipa, R. R. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0126-z (2018).
Dasgupta, B. & Chhipa, R. R. Trends Pharmacol. Sci. 37, 192–206 (2016).
Koo, S. H. et al. Nature 437, 1109–1114 (2005).
Jones, R. G. et al. Mol. Cell 18, 283–293 (2005).
Ivan, M. et al. Science 292, 464–468 (2001).
Li, Z. et al. Cancer Cell 15, 501–513 (2009).
Rios, M. et al. Cancer Res. 73, 2628–2638 (2013).
Park, H. U. et al. Mol. Cancer Ther. 8, 733–741 (2009).
Faubert, B. et al. Cell Metab. 17, 113–124 (2013).
Ji, H. et al. Nature 448, 807–810 (2007).
Zadra, G. et al. Mol. Cancer Res. 13, 1059–1072 (2015).
Li, W. et al. Oncotarget 6, 7365–7378 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Leli, N.M., Koumenis, C. Pro-tumorigenic AMPK in glioblastoma. Nat Cell Biol 20, 736–737 (2018). https://doi.org/10.1038/s41556-018-0129-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-018-0129-9
- Springer Nature Limited