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NON-CODING RNA

A lncRNA GUARDINg genome integrity

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A coordinated DNA damage response mediated by p53 to repair DNA lesions or to promote apoptosis is essential for maintenance of genome stability. A study now unveils the long non-coding RNA GUARDIN as a component of this pathway, which protects genome integrity in a pleiotropic fashion.

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Fig. 1: GUARDIN preserves genome integrity through multiple mechanisms.

References

  1. Reinhardt, H. C. & Schumacher, B. Trends Genet. 28, 128–136 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Grossi, E., Sanchez, Y. & Huarte, M. Biochim. Biophys. Acta 1859, 200–208 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. Hu W. L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0066-7 (2018).

  4. Tarasov, V. et al. Cell Cycle 6, 1586–1593 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Thomson, D. W. & Dinger, M. E. Nat. Rev. Genet. 17, 272–283 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Feuerhahn, S., Chen, L. Y., Luke, B. & Porro, A. Trends Biochem. Sci. 40, 275–285 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Henderson, B. R. Bioessays 27, 884–893 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Li, M. & Yu, X. Cancer Cell 23, 693–704 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zhang, Y. et al. Nat. Struct. Mol. Biol. 23, 522–530 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. The Cancer Genome Atlas Network. Nature 490, 61–70 (2012).

    Article  PubMed Central  Google Scholar 

  11. Matsui, M. & Corey, D. R. Nat. Rev. Drug. Discov. 16, 167–179 (2017).

    Article  CAS  PubMed  Google Scholar 

  12. Nickoloff, J. A., Jones, D., Lee, S. H., Williamson, E. A. & Hromas, R. J. Natl. Cancer Inst. 109, djx059 (2017).

    Article  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

    Elena Grossi & Maite Huarte

  2. Health Research Institute of Navarra (IdiSNA), Pamplona, Spain

    Elena Grossi & Maite Huarte

Authors
  1. Elena Grossi
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  2. Maite Huarte
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Correspondence to Maite Huarte.

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The authors declare no competing interests.

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Grossi, E., Huarte, M. A lncRNA GUARDINg genome integrity. Nat Cell Biol 20, 371–372 (2018). https://doi.org/10.1038/s41556-018-0075-6

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