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Mineralized bacteria as an immunotherapy agent against various cancer types

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By coating manganese dioxide on the surface of fixed bacteria, we obtained mineralized bacteria with the ability to potently activate multiple immune signalling pathways. Immunotherapy with mineralized bacteria suppressed various types of cancer in multiple animal models, eliciting both immune memory and abscopal antitumour effects.

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Fig. 1: Synthesis and antitumour process of oncolytic mineralized bacteria.

References

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This is a summary of: Wang, C. et al. Oncolytic mineralized bacteria as potent locally administered immunotherapeutics. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01191-w (2024).

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Mineralized bacteria as an immunotherapy agent against various cancer types. Nat. Biomed. Eng (2024). https://doi.org/10.1038/s41551-024-01192-9

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