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Engineering cell-derived extracellular vesicles for gene therapy

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Many genetic therapies are limited by a lack of methods for delivering them to target cells in the body. We have developed technologies to engineer biological nanovesicles to load therapeutic proteins, target recipient immune cells and deliver Cas9 to knock out CXCR4 in primary human T cells.

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Fig. 1: The GEMINI strategy for producing multifunctional EVs.

References

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This is a summary of: Stranford, D. M. et al. Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01142-x (2023).

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Engineering cell-derived extracellular vesicles for gene therapy. Nat. Biomed. Eng 8, 343–344 (2024). https://doi.org/10.1038/s41551-023-01167-2

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  • DOI: https://doi.org/10.1038/s41551-023-01167-2

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