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Assessing the toxicity of bispecific antibodies

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The on-target off-tumour toxicities of T-cell-engaging bispecific antibodies in patients can be captured in intestinal organoids derived from the patients’ biopsied tissue and supplemented with immune cells.

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Fig. 1: Organoid models generated from healthy and malignant intestinal tissues and co-cultured with allogeneic T cells for the study of the on-target off-tumour toxicities of TCBs.

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Authors and Affiliations

  1. Centre for Tumour Biology, Barts Cancer Institute, Charterhouse Square, London, UK

    Marta Buzzetti & Marco Gerlinger

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  1. Marta Buzzetti
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  2. Marco Gerlinger
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Correspondence to Marco Gerlinger.

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Competing interests

M.G. receives institutional research funding from Bristol Myers Squibb, Merck KG and Roche, speaker fees from Bristol Myers Squibb and Merck KG, and expert advisory fees from Merck Sharp and Dohme and Roche.

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Buzzetti, M., Gerlinger, M. Assessing the toxicity of bispecific antibodies. Nat. Biomed. Eng 8, 339–340 (2024). https://doi.org/10.1038/s41551-023-01163-6

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