Skip to main content
Log in

Diagnostics

DNA-based computation for multiple biomarkers

  • News & Views
  • Published:

From Nature Biomedical Engineering

View current issue Submit your manuscript
  • 4 Altmetric

DNA-based molecular computation allows for the simultaneous detection of multiple types of biomarker, as shown for the accurate identification of prostate cancer in serum samples on the basis of specific RNAs, proteins and small molecules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: DNA-encoded multidimensional molecular classifiers applied to the identification of prostate cancer in serum samples.

References

  1. Vargas, A. J. et al. Nat. Rev. Cancer 16, 525–537 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Collins, F. S. et al. N. Engl. J. Med. 372, 793–795 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Blanc, T. et al. Nat. Methods 17, 1100–1102 (2020).

    Article  PubMed  CAS  Google Scholar 

  4. Tarazona, S. et al. Nat. Comput. Sci. 1, 395–402 (2021).

    Article  Google Scholar 

  5. Kieffer, C. et al. Adv. Biol. 7, e2200203 (2023).

    Article  Google Scholar 

  6. Zhang, D. Y. et al. Nat. Chem. 3, 103–113 (2011).

    Article  PubMed  CAS  Google Scholar 

  7. Lopez, R. et al. Nat. Chem. 10, 746–754 (2018).

    Article  PubMed  CAS  Google Scholar 

  8. Zhang, C. et al. Nat. Nanotechnol. 15, 709–715 (2020).

    Article  PubMed  Google Scholar 

  9. Yin, F. et al. Nat. Nanotechnol. https://doi.org/10.1038/s41565-023-01348-9 (2023).

    Article  PubMed  Google Scholar 

  10. Reischl, U. & Kochanowski, B. Mol. Biotechnol. 3, 55–71 (1995).

    Article  PubMed  CAS  Google Scholar 

  11. Tanaka, G. et al. Neural Netw. 115, 100–123 (2019).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hao Yan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yu, L., Yan, H. DNA-based computation for multiple biomarkers. Nat. Biomed. Eng 7, 1535–1536 (2023). https://doi.org/10.1038/s41551-023-01161-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-023-01161-8

  • Springer Nature Limited

Navigation