Skip to main content
SpringerLink
Log in

Mechanopathology

Bone mineral slows down breast cancer cells

  • News & Views
  • Published:

From Nature Biomedical Engineering

View current issue Submit your manuscript

In breast cancer metastasized to bone, the mineralization of collagen regulates integrin-mediated mechanosignalling, inducing a less proliferative phenotype in breast cancer cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Collagen mineralization regulates the phenotypes of breast cancer cells in bone metastases.

References

  1. Zhang, Y. et al. N. Engl. J. Med. 336, 611–617 (1997).

    Article  CAS  PubMed  Google Scholar 

  2. Zmuda, J. M. et al. J. Natl Cancer Inst. 93, 930–936 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Kraemer, B. et al. Anticancer Res. 31, 4423–4428 (2011).

    CAS  PubMed  Google Scholar 

  4. Chen, H. M., Chen, F. P., Yang, K. C. & Yuan, S. S. JAMA Netw. Open 2, e190429 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Choi, S. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01077-3 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Esposito, M., Guise, T. & Kang, Y. Cold Spring Harb. Perspect. Med. 8, a031252 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Schrader, J. et al. Hepatology 53, 1192 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Fattet, L. et al. Dev. Cell 54, 302–316.e7 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Seref-Ferlengez, Z. et al. PLoS ONE 11, e0155107 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Laranga, R. et al. Cancers 12, 2315 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Aponte, P. M. & Caicedo, A. Stem Cells Int. 2017, 5619472 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Talukdar, S. et al. Proc. Natl Acad. Sci. USA 115, 5768–5773 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Cheyenne Ernst & Hai Wang

Authors
  1. Cheyenne Ernst
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hai Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hai Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ernst, C., Wang, H. Bone mineral slows down breast cancer cells. Nat. Biomed. Eng 7, 1346–1347 (2023). https://doi.org/10.1038/s41551-023-01122-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-023-01122-1

  • Springer Nature Limited

Search

Navigation