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Immunotherapy

Anchoring immunosuppression to inflamed tissue

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Fusing the anti-inflammatory enzyme indoleamine 2,3-dioxygenase to the tissue-anchoring protein galectin-3 ameliorates inflammation at the injection site while avoiding systemic immune suppression, as shown in multiple rodent models of inflammation.

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Fig. 1: Effects of the IDO–Gal3 fusion protein in rodent models of inflammation.

References

  1. Martino, M. M. et al. Science 343, 885–888 (2014).

    Article  CAS  PubMed  Google Scholar 

  2. Mariño, K. V., Cagnoni, A. J., Croci, D. O. & Rabinovich, G. A. Nat. Rev. Drug Discov. 22, 295–316 (2023).

    Article  PubMed  Google Scholar 

  3. Cummings, R. D., Liu, F.-T., Rabinovich, G. A., Stowell, S. R. & Vasta, G. R. in Essentials of Glycobiology 4th edn (eds Varki, A. et al.) Ch. 36 (Cold Spring Harbor Laboratory Press, 2022).

  4. Farhadi, S. A. et al. Nat. Commun. 9, 4943 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Munn, D. H. & Mellor, A. L. Trends Immunol. 34, 137–143 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Liu, M. et al. J. Hematol. Oncol. 11, 100 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Hayashi, T. et al. J. Clin. Invest. 114, 270–279 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bracho-Sanchez, E. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01025-1 (2023).

    Article  PubMed  Google Scholar 

  9. Salomonsson, E. et al. J. Biol. Chem. 285, 35079–35091 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Eckardt, V. et al. EMBO Rep. 21, e47852 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sanjurjo, L., Broekhuizen, E. C., Koenen, R. R. & Thijssen, V. L. J. L. Biomolecules 12, 1286 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Gabriel A. Rabinovich.

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Mariño, K.V., Blidner, A.G. & Rabinovich, G.A. Anchoring immunosuppression to inflamed tissue. Nat. Biomed. Eng 7, 1060–1062 (2023). https://doi.org/10.1038/s41551-023-01055-9

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