Fusing the anti-inflammatory enzyme indoleamine 2,3-dioxygenase to the tissue-anchoring protein galectin-3 ameliorates inflammation at the injection site while avoiding systemic immune suppression, as shown in multiple rodent models of inflammation.
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Mariño, K.V., Blidner, A.G. & Rabinovich, G.A. Anchoring immunosuppression to inflamed tissue. Nat. Biomed. Eng 7, 1060–1062 (2023). https://doi.org/10.1038/s41551-023-01055-9
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DOI: https://doi.org/10.1038/s41551-023-01055-9
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