Liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules enable the mapping, via magnetic resonance imaging, of spatial variations of light intensity in illuminated brain tissue in living animals.
References
Simon, J., Schwalm, M., Morstein, J., Trauner, D. & Jasanoff, A. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00982-3 (2022).
Davila, H. V. et al. Nat. New Biol. 241, 159–160 (1973).
Brown, J. E. Biophys. J. 15, 1155–1160 (1975).
Tsien, R. Y. Biochem. 19, 2396–2404 (1980).
Miyawaki, A. et al. Nature 388, 882–887 (1997).
Siegel, M. S. & Isacoff, E. Y. Neuron 19, 735–741 (1997).
Zemelman, B. V. et al. Neuron 33, 15–22 (2002).
Boyden, E. S. et al. Nat. Neurosci. 8, 1263–1268 (2005).
Donthamsetti, P. C. et al. J. Am. Chem. Soc. 141, 11522–11530 (2019).
Sahel, J. A. et al. Nat. Med. 27, 1223–1229 (2021).
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Singh, A., McMahon, M.T. Mapping light distribution in the brain via MRI. Nat. Biomed. Eng 7, 199–201 (2023). https://doi.org/10.1038/s41551-022-00995-y
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DOI: https://doi.org/10.1038/s41551-022-00995-y
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