The inability to precisely manipulate mammalian mitochondrial DNA has stalled our understanding of mitochondrial biology and the generation of cellular and animal models in which to study it. DNA base editing technologies have enabled the generation of a library of mitochondrial base editors that precisely ablate every protein-coding gene in the mouse mitochondrial genome.
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References
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This is a summary of: Silva-Pinheiro, P. et al. A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00968-1 (2022).
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Base editing ablates all protein-coding genes of the mitochondrial genome in mouse cells. Nat. Biomed. Eng 7, 614–615 (2023). https://doi.org/10.1038/s41551-022-00986-z
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DOI: https://doi.org/10.1038/s41551-022-00986-z
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