Developing gene therapy for use in the central nervous system has been hampered by the lack of an efficient vector for gene delivery. We report an adeno-associated virus vector with an enhanced ability to cross the blood–brain barrier in both rodents and non-human primates, and use it to develop systemic anti-tumour gene therapies for glioblastoma.
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This is a summary of: Yao, Y. et al. Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood–brain barrier in rodents and primates. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-022-00938-7 (2022).
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An adeno-associated virus vector penetrates the blood–brain barrier in non-human primates. Nat. Biomed. Eng 6, 1201–1202 (2022). https://doi.org/10.1038/s41551-022-00939-6
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DOI: https://doi.org/10.1038/s41551-022-00939-6
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