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Chemomechanically antifibrotic stromal cells

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Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.

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Fig. 1: MSCs modulate their antifibrotic behaviour in response to chemical and mechanical cues.

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Authors and Affiliations

  1. Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA

    Michael V. Schrodt & James A. Ankrum

  2. Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, USA

    Michael V. Schrodt & James A. Ankrum

Authors
  1. Michael V. Schrodt
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  2. James A. Ankrum
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Correspondence to James A. Ankrum.

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Schrodt, M.V., Ankrum, J.A. Chemomechanically antifibrotic stromal cells. Nat Biomed Eng 6, 6–7 (2022). https://doi.org/10.1038/s41551-021-00840-8

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