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Bacterial couriers as cancer vaccines

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Flagellated bacteria coated with antigen-adsorbing nanoparticles and injected into irradiated tumours elicit systemic antitumour immune responses by transporting tumour antigens towards the tumour periphery, where they are taken up by functional antigen-presenting cells.

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Fig. 1: Motile bacteria coated with antigen-adsorbing nanoparticles trigger antitumour immunity following radiotherapy.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Columbia University, New York, NY, USA

    Andrew Redenti, Jaeseung Hahn & Tal Danino

  2. Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA

    Tal Danino

  3. Data Science Institute, Columbia University, New York, NY, USA

    Tal Danino

Authors
  1. Andrew Redenti
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  2. Jaeseung Hahn
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  3. Tal Danino
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Corresponding author

Correspondence to Tal Danino.

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The authors declare no competing interests.

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Redenti, A., Hahn, J. & Danino, T. Bacterial couriers as cancer vaccines. Nat Biomed Eng 6, 3–5 (2022). https://doi.org/10.1038/s41551-021-00839-1

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