The phagocytic clearance of the large fraction of transplanted cells that typically undergo rapid cell death contributes to therapeutic outcomes.
References
Martin, I., Galipeau, J., Kessler, C., Blanc, K. L. & Dazzi, F. Sci. Transl. Med. 11, eaat2189 (2019).
Galipeau, J. & Sensébé, L. Cell Stem Cell 22, 824–833 (2018).
Bianco, P. et al. Nat. Med. 19, 35–42 (2013).
Fibbe, W. E., Dazzi, F. & LeBlanc, K. Nat. Med. 19, 812–813 (2013).
Cyranoski, D. Nature 565, 544–545 (2019).
Panés, J. et al. Lancet 388, 1281–1290 (2016).
Sipp, D., Robey, P. G. & Turner, L. Nature 561, 455–457 (2018).
Caplan, A. I. Nature 566, 39 (2019).
Galipeau, J., Weiss, D. J. & Dominici, M. Cytotherapy 21, 1–2 (2019).
Caplan, A. I. J. Orthop. Res. 9, 641–650 (1991).
Caplan, A. I. Stem Cells Transl. Med. 6, 1445–1451 (2017).
Singer, N. G. & Caplan, A. I. Annu. Rev. Pathol. 6, 457–478 (2011).
Uccelli, A., Moretta, L. & Pistoia, V. Nat. Rev. Immunol. 8, 726–736 (2008).
Leibacher, J. & Henschler, R. Stem Cell Res. Ther. 7, 7 (2016).
Parekkadan, B. & Milwid, J. M. Annu. Rev. Biomed. Eng. 12, 87–117 (2010).
Ankrum, J. & Karp, J. M. Trends Mol. Med. 16, 203–209 (2010).
Salvadori, M. et al. Mol. Ther. Methods Clin. Dev. 14, 1–15 (2019).
Moll, G. et al. Adv. Exp. Med. Biol. 951, 77–98 (2016).
Fischer, U. M. et al. Stem Cells Dev. 18, 683–691 (2009).
Eggenhofer, E. et al. Front. Immunol. 3, 297 (2012).
von Bahr, L. et al. Stem Cells 30, 1575–1578 (2012).
Liu, L. et al. EBioMedicine 47, 563–577 (2019).
Ghahremani Piraghaj, M. et al. Life Sci. 212, 203–212 (2018).
Eggenhofer, E., Luk, F., Dahlke, M. H. & Hoogduijn, M. J. Front. Immunol. 5, 148 (2014).
Braza, F. et al. Stem Cells 34, 1836–1845 (2016).
Mathias, L. J. et al. J. Immunol. 191, 5914–5924 (2013).
Jiang, Y. et al. Basic Res. Cardiol. 105, 431–442 (2010).
Lu, W. et al. Int. J. Cardiol. 165, 333–340 (2013).
Ben-Mordechai, T. et al. J. Am. Coll. Cardiol. 62, 1890–1901 (2013).
Thum, T., Bauersachs, J., Poole-Wilson, P. A., Volk, H.-D. & Anker, S. D. J. Am. Coll. Cardiol. 46, 1799–1802 (2005).
Carty, F., Mahon, B. P. & English, K. Clin. Exp. Immunol. 188, 1–11 (2017).
de Witte, S. F. H. et al. Stem Cells 36, 602–615 (2018).
Luk, F. et al. Stem Cells Dev. 25, 1342–1354 (2016).
Galleu, A. et al. Sci. Transl. Med. 9, eaam7828 (2017).
Abdolmaleki, F. et al. Front. Immunol. 9, 1645 (2018).
Nagata, S., Hanayama, R. & Kawane, K. Cell 140, 619–630 (2010).
Boada-Romero, E., Martinez, J., Heckmann, B. L. & Green, D. R. Nat. Rev. Mol. Cell Biol. 21, 398–414 (2020).
Poon, I. K. H., Lucas, C. D., Rossi, A. G. & Ravichandran, K. S. Nat. Rev. Immunol. 14, 166–180 (2014).
Weiss, D. J. et al. Front. Immunol. 10, 1191 (2019).
Jackson, M. V. et al. Stem Cells 34, 2210–2223 (2016).
Fleshner, M. & Crane, C. R. Trends Immunol. 38, 768–776 (2017).
Németh, K. et al. Nat. Med. 15, 42–49 (2009).
Jäger, R. & Fearnhead, H. O. Biochem. Res. Int. 2012, e453838 (2012).
Cheung, T. S., Galleu, A., von Bonin, M., Bornhäuser, M. & Dazzi, F. Haematologica 104, e438–e441 (2019).
Riazifar, M. et al. ACS Nano 13, 6670–6688 (2019).
Gonçalves, Fd. C. et al. Sci. Rep. 7, 12100 (2017).
Phinney, D. G. et al. Nat. Commun. 6, 8472 (2015).
Lalu, M. M. et al. PLoS ONE 7, e47559 (2012).
Moll, G. et al. Stem Cells 30, 1565–1574 (2012).
Moll, G. et al. Trends Mol. Med. 25, 149–163 (2019).
Moll, G. & Blanc, K. L. ISBT Sci. Ser. 10, 357–365 (2015).
Hicks, A. U., MacLellan, C. L., Chernenko, G. A. & Corbett, D. Brain Res. 1231, 103–112 (2008).
Liao, L.-Y., Lau, B. W.-M., Sánchez-Vidaña, D. I. & Gao, Q. Neural Regen. Res. 14, 1129–1137 (2019).
Donegà, M., Giusto, E., Cossetti, C. & Pluchino, S. in Neural Stem Cells: New Perspectives https://doi.org/10.5772/55426 (IntechOpen, 2013).
Vannella, K. M. & Wynn, T. A. Annu. Rev. Physiol. 79, 593–617 (2017).
Wynn, T. A. & Vannella, K. M. Immunity 44, 450–462 (2016).
Mosser, D. M. & Edwards, J. P. Nat. Rev. Immunol. 8, 958–969 (2008).
Korns, D. R. P., Frasch, S. C. P., Fernandez-Boyanapalli, R. P., Henson, P. M. P. & Bratton, D. L. M. Front. Immunol. 2, 57 (2011).
Spiller, K. L. & Koh, T. J. Adv. Drug Deliv. Rev. 122, 74–83 (2017).
Yin, J. Q., Zhu, J. & Ankrum, J. A. Nat. Biomed. Eng. 3, 90–104 (2019).
Stabler, C. L., Li, Y., Stewart, J. M. & Keselowsky, B. G. Nat. Rev. Mater. 4, 429–450 (2019).
Tuettenberg, A., Steinbrink, K. & Schuppan, D. Nanomedicine 11, 2735–2751 (2016).
Smith, T. D., Nagalla, R. R., Chen, E. Y. & Liu, W. F. Adv. Drug Deliv. Rev. 114, 193–205 (2017).
Ankrum, J. A., Dastidar, R. G., Ong, J. F., Levy, O. & Karp, J. M. Sci. Rep. 4, 4645 (2014).
Zhang, F. et al. Nat. Commun. 10, 3974 (2019).
Phinney, D. G. & Pittenger, M. F. Stem Cells 35, 851–858 (2017).
Théry, C., Ostrowski, M. & Segura, E. Nat. Rev. Immunol. 9, 581–593 (2009).
Riazifar, M., Pone, E. J., Lötvall, J. & Zhao, W. Annu. Rev. Pharmacol. Toxicol. 57, 125–154 (2017).
Armstrong, J. P. K., Holme, M. N. & Stevens, M. M. ACS Nano 11, 69–83 (2017).
Harel-Adar, T. et al. Proc. Natl Acad. Sci. USA 108, 1827–1832 (2011).
Bagalkot, V., Deiuliis, J. A., Rajagopalan, S. & Maiseyeu, A. Adv. Drug Deliv. Rev. 99, 2–11 (2016).
Saas, P., Daguindau, E. & Perruche, S. Stem Cells 34, 1464–1473 (2016).
Pilon, C. et al. Front. Immunol. 10, 2908 (2019).
Zhang, B. et al. Cytotherapy 20, 687–696 (2018).
Shigemoto-Kuroda, T. et al. Stem Cell Rep. 8, 1214–1225 (2017).
Lankford, K. L. et al. PLoS ONE 13, e0190358 (2018).
Henao Agudelo, J. S. et al. Front. Immunol. 8, 881 (2017).
Song, Y. et al. Stem Cells 35, 1208–1221 (2017).
Domenis, R. et al. Sci. Rep. 8, 13325 (2018).
Patel, A. N. et al. Lancet 387, 2412–2421 (2016).
Giri, J. & Galipeau, J. Blood Adv. 4, 1987–1997 (2020).
Giri, J., Das, R., Nylen, E., Chinnadurai, R. & Galipeau, J. Cell Rep. 30, 1923–1934.e4 (2020).
Shi, Y. et al. Nat. Rev. Nephrol. 14, 493–507 (2018).
Matthay, M. A. et al. Lancet Respir. Med. 7, 154–162 (2019).
Caplan, H. et al. Front. Immunol. 10, 1645 (2019).
Kallmeyer, K. et al. Stem Cells Transl. Med. 9, 131–144 (2019).
Braid, L. R., Wood, C. A., Wiese, D. M. & Ford, B. N. Cytotherapy 20, 232–244 (2018).
Le Blanc, K. et al. Lancet 363, 1439–1441 (2004).
Segaliny, A. I. et al. EBioMedicine 45, 39–57 (2019).
Liao, W. et al. Biomaterials 77, 87–97 (2016).
Gupta, N. et al. J. Immunol. 179, 1855–1863 (2007).
Kavanagh, H. & Mahon, B. P. Allergy 66, 523–531 (2011).
Sun, J. et al. Cell. Physiol. Biochem. 27, 587–596 (2011).
Chang, C.-L. et al. J. Transl. Med. 10, 244 (2012).
Acknowledgements
We thank J. Gu for helpful comments. This work was supported by the NIH grants 1DP2CA195763, R21CA219225 and P2CHD086843 (the Alliance for Regenerative Rehabilitation Research & Training; AR3T), and by DOD/CDMRP W81XWH-17-1-0522 and NSF/SBIR no. 1913404.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
W.Z. is a co-founder of Velox Biosystems Inc., Amberstone Biosciences Inc. and Arvetas Biosciences Inc.
Rights and permissions
About this article
Cite this article
Wagoner, Z.W., Zhao, W. Therapeutic implications of transplanted-cell death. Nat Biomed Eng 5, 379–384 (2021). https://doi.org/10.1038/s41551-021-00729-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-021-00729-6
- Springer Nature Limited
This article is cited by
-
Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Psoriasis Through TNF-α/NF-κB/MMP13 Pathway
Inflammation (2023)
-
Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice
Journal of Nanobiotechnology (2022)
-
Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury
Stem Cell Research & Therapy (2021)