Systemic viral delivery of a gene encoding for a light-sensitive red-shifted ion channel enables non-invasive neuronal stimulation deep in the brain of rodents.
References
Marshel, J. H. et al. Science 365, eaaw5202 (2019).
Chen, R. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-020-0679-9 (2020).
Chan, K. Y. et al. Nat. Neurosci. 20, 1172–1179 (2017).
Bedbrook, C. N. et al. Nat. Methods 16, 1176–1184 (2019).
Chen, R., Romero, G., Christiansen, M. G., Mohr, A. & Anikeeva, P. Science 347, 1477–1480 (2015).
Stanley, S. A. et al. Nature 531, 647–650 (2016).
Ibsen, S., Tong, A., Schutt, C., Esener, S. & Chalasani, S. H. Nat. Commun. 6, 8264 (2015).
Qiu, Z. et al. Cell Rep. 32, 108033 (2020).
Yizhar, O. et al. Nature 477, 171–178 (2011).
Lin, J. Y., Knutsen, P. M., Muller, A., Kleinfeld, D. & Tsien, R. Y. Nat. Neurosci. 16, 1499–1508 (2013).
Chuong, A. S. et al. Nat. Neurosci. 17, 1123–1129 (2014).
Chen, S. et al. Science 359, 679–684 (2018).
Matsubara, T. et al. Preprint at bioRxiv https://doi.org/10.1101/798702 (2020).
Gong, X. et al. Neuron 107, 38–51 (2020).
Grossman, N. et al. Cell 169, 1029–1041 (2017).
Legon, W. et al. Nat. Neurosci. 17, 322–329 (2014).
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Chen, S., McHugh, T.J. Further-reaching optogenetics. Nat Biomed Eng 4, 1028–1029 (2020). https://doi.org/10.1038/s41551-020-00648-y
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DOI: https://doi.org/10.1038/s41551-020-00648-y
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