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DEEP BRAIN STIMULATION

Further-reaching optogenetics

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Systemic viral delivery of a gene encoding for a light-sensitive red-shifted ion channel enables non-invasive neuronal stimulation deep in the brain of rodents.

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Fig. 1: Ion channels and types of stimuli for non-invasive deep brain stimulation.

References

  1. Marshel, J. H. et al. Science 365, eaaw5202 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chen, R. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-020-0679-9 (2020).

  3. Chan, K. Y. et al. Nat. Neurosci. 20, 1172–1179 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bedbrook, C. N. et al. Nat. Methods 16, 1176–1184 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Chen, R., Romero, G., Christiansen, M. G., Mohr, A. & Anikeeva, P. Science 347, 1477–1480 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Stanley, S. A. et al. Nature 531, 647–650 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ibsen, S., Tong, A., Schutt, C., Esener, S. & Chalasani, S. H. Nat. Commun. 6, 8264 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Qiu, Z. et al. Cell Rep. 32, 108033 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Yizhar, O. et al. Nature 477, 171–178 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Lin, J. Y., Knutsen, P. M., Muller, A., Kleinfeld, D. & Tsien, R. Y. Nat. Neurosci. 16, 1499–1508 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chuong, A. S. et al. Nat. Neurosci. 17, 1123–1129 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chen, S. et al. Science 359, 679–684 (2018).

    Article  CAS  PubMed  Google Scholar 

  13. Matsubara, T. et al. Preprint at bioRxiv https://doi.org/10.1101/798702 (2020).

  14. Gong, X. et al. Neuron 107, 38–51 (2020).

    Article  CAS  PubMed  Google Scholar 

  15. Grossman, N. et al. Cell 169, 1029–1041 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Legon, W. et al. Nat. Neurosci. 17, 322–329 (2014).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Thomas J. McHugh.

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Chen, S., McHugh, T.J. Further-reaching optogenetics. Nat Biomed Eng 4, 1028–1029 (2020). https://doi.org/10.1038/s41551-020-00648-y

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