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CANCER IMMUNOTHERAPY

Prevention of CAR-T-cell dysfunction

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The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.

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Fig. 1: c-Jun overexpression prevents T-cell dysfunction.

References

  1. Long, A. H. et al. Nat. Med. 21, 581–590 (2015).

    Article  CAS  Google Scholar 

  2. Fraietta, J. A. et al. Nat. Med. 24, 563–571 (2018).

    Article  CAS  Google Scholar 

  3. Lynn, R. C. et al. Nature https://doi.org/10.1038/s41586-019-1805-z (2019).

    Article  CAS  Google Scholar 

  4. Man, K. et al. Immunity 47, 1129–1141 (2017).

    Article  CAS  Google Scholar 

  5. Quigley, M. et al. Nat. Med. 16, 1147–1151 (2010).

    Article  CAS  Google Scholar 

  6. Pauken, K. E. et al. Science 354, 1160–1165 (2016).

    Article  CAS  Google Scholar 

  7. Sen, D. R. et al. Science 354, 1165–1169 (2016).

    Article  CAS  Google Scholar 

  8. Paley, M. A. et al. Science 338, 1220–1225 (2012).

    Article  CAS  Google Scholar 

  9. Miller, B. C. et al. Nat. Immunol. 20, 326–336 (2019).

    Article  CAS  Google Scholar 

  10. Martinez, G. J. et al. Immunity 42, 265–278 (2015).

    Article  CAS  Google Scholar 

  11. Liu, X. et al. Nature 567, 525–529 (2019).

    Article  CAS  Google Scholar 

  12. Khan, O. et al. Nature 571, 211–218 (2019).

    Article  CAS  Google Scholar 

  13. Porter, D. L. et al. Sci. Transl. Med. 7, 303ra139 (2015).

    Article  Google Scholar 

  14. Walker, A. J. et al. Mol. Ther. 25, 2189–2201 (2017).

    Article  CAS  Google Scholar 

  15. Sadelain, M., Rivière, I. & Riddell, S. Nature 545, 423–431 (2017).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA

    Martin W. LaFleur, Brian C. Miller & Arlene H. Sharpe

  2. Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA

    Martin W. LaFleur, Brian C. Miller & Arlene H. Sharpe

  3. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA

    Martin W. LaFleur, Brian C. Miller & Arlene H. Sharpe

  4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

    Brian C. Miller

Authors
  1. Martin W. LaFleur
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  2. Brian C. Miller
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  3. Arlene H. Sharpe
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Corresponding author

Correspondence to Arlene H. Sharpe.

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Competing interests

A.H.S. has patents on the PD-L1/PD-L2/PD-1 pathway and on tumour immunotherapy licensed by Roche, Genentech and Novartis (US patent nos. 7,432,059, 7,722,868, 8,652,465, 9,457,080, 9,683,048, 9,815,898, 9,845,356, 9,988,452, 10,202,454 and 10,370,446), consults for Novartis, serves on the scientific advisory boards for Surface Oncology, SQZ Biotech, Elstar Therapeutics, Elpiscience, Selecta and Monopteros, and has received research funding from Merck, Novartis, Roche, Ipsen, UCB and Quark Ventures. The remaining authors declare no competing interests.

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LaFleur, M.W., Miller, B.C. & Sharpe, A.H. Prevention of CAR-T-cell dysfunction. Nat Biomed Eng 4, 16–17 (2020). https://doi.org/10.1038/s41551-019-0512-2

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