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Weakly immunogenic CRISPR therapies

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Orthologues of CRISPR-associated proteins and of viral vectors evade immune recognition in mice, enabling repeated gene therapy.

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Fig. 1: Potential methods for reducing immune responses to Cas9.

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Authors and Affiliations

  1. Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA

    Eric A. Wilson & Karen S. Anderson

Authors
  1. Eric A. Wilson
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  2. Karen S. Anderson
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Correspondence to Karen S. Anderson.

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Competing interests

K.S.A. is noted as an inventor on a patent application regarding Cas9 immunity.

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Wilson, E.A., Anderson, K.S. Weakly immunogenic CRISPR therapies. Nat Biomed Eng 3, 761–762 (2019). https://doi.org/10.1038/s41551-019-0463-7

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