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Targeted killing of virulent Vibrio cholerae

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Plasmids coding for a toxin gene that is only expressed in the presence of a virulence-associated transcription factor lead to the killing of only the virulent form of the bacterium Vibrio cholerae in a mixed bacterial population.

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Fig. 1: A toxin–intein complex selectively kills pathogenic V. cholerae.

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  1. Departments of Microbiology, Medicine and Cell Biology, New York University School of Medicine, New York, NY, USA

    Richard Novick

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  1. Richard Novick
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Correspondence to Richard Novick.

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Competing interests

The author is a co-inventor on a patent application for a non-antibiotic method of treating bacterial infections.

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Novick, R. Targeted killing of virulent Vibrio cholerae. Nat Biomed Eng 3, 507–508 (2019). https://doi.org/10.1038/s41551-019-0419-y

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