A humanized biomaterial microenvironment that mimics the pre-metastatic niche captures disseminated tumour cells and recapitulates metastatic progression after implantation in xenografted mice.
This is a preview of subscription content, log in via an institution to check access.
References
Steeg, P. S. Nat. Rev. Cancer 16, 201–218 (2016).
Peinado, H. et al. Nat. Rev. Cancer 17, 302–317 (2017).
Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Nat. Rev. Cancer 14, 611–622 (2014).
Ghajar, C. M. et al. Nat. Cell Biol. 15, 807–817 (2013).
Aguado, B. A., Bushnell, G. G., Rao, S. S., Jeruss, J. S. & Shea, L. D. Nat. Biomed. Eng. 1, 0077 (2017).
Mohme, M., Riethdorf, S. & Pantel, K. Nat. Rev. Clin. Oncol. 14, 155–167 (2017).
Gu, L. & Mooney, D. J. Nat. Rev. Cancer 16, 56–66 (2016).
Wang, F. et al. Proc. Natl Acad. Sci. USA 95, 14821–14826 (1998).
Carpenter, R. A., Kwak, J.-G., Peyton, S. R. & Lee, J. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0307-x (2018).
Chung, K. et al. Nature 497, 332–337 (2013).
Rao, S. S. et al. Cancer Res. 76, 5209–5218 (2016).
Azarin, S. M. et al. Nat. Commun. 6, 8094 (2015).
Vermesh, O. et al. Nat. Biomed. Eng. 2, 696–705 (2018).
Kang, Y. & Pantel, K. Cancer Cell 23, 573–581 (2013).
Oudin, M. J. & Weaver, V. M. Cold Spring Harb. Lab. Sym. 81, 189–205 (2016).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Matei, I., Rampersaud, S. & Lyden, D. Engineered niches model the onset of metastasis. Nat Biomed Eng 2, 885–887 (2018). https://doi.org/10.1038/s41551-018-0326-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-018-0326-7
- Springer Nature Limited