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Macrophages rescue injured engineered muscle

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Engineered skeletal muscle self-repairs when incorporating bone-marrow-derived macrophages, which prevent the apoptosis of resident muscle stem cells.

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Fig. 1: BMDMs enhance the survival of adult MuSCs in 3D bioengineered skeletal muscle.

References

  1. Blau, H. M., Cosgrove, B. D. & Ho, A. T. V. Nat. Med. 21, 854–862 (2015).

    Article  CAS  Google Scholar 

  2. Bentzinger, C. F., Wang, Y. X., Dumont, N. A. & Rudnicki, M. A. EMBO Rep. 14, 1062–1072 (2013).

    Article  CAS  Google Scholar 

  3. Cosgrove, B. D. et al. Nat. Med. 20, 255–264 (2014).

    Article  CAS  Google Scholar 

  4. Sampath, S. C. et al. Nat. Commun. 9, 1531 (2018).

    Article  Google Scholar 

  5. Madl, C. M., Heilshorn, S. C. & Blau, H. M. Nature 557, 335–342 (2018).

    Article  CAS  Google Scholar 

  6. Quarta, M. et al. Nat. Biotechnol. 34, 752–759 (2016).

    Article  CAS  Google Scholar 

  7. Juhas, M., Engelmayr, G. C., Fontanella, A. N., Palmer, G. M. & Bursac, N. Proc. Natl Acad. Sci. USA 111, 5508–5513 (2014).

    Article  CAS  Google Scholar 

  8. Wang, Y. X. & Rudnicki, M. A. Nat. Rev. Mol. Cell Biol. 13, 127–133 (2012).

    Article  CAS  Google Scholar 

  9. Zhang, H. et al. Science 352, aaf2693 (2016).

    Google Scholar 

  10. Ho, A. T. V. et al. Proc. Natl Acad. Sci. USA 114, 6675–6684 (2017).

    CAS  PubMed  Google Scholar 

  11. Juhas, M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0290-2 (2018).

  12. Tidball, J. G. Nat. Rev. Immunol. 17, 165–178 (2017).

    Article  CAS  Google Scholar 

  13. Chazaud, B. et al. J. Cell Biol. 163, 1133–1143 (2003).

    Article  CAS  Google Scholar 

  14. Varga, T. et al. Immunity 45, 1038–1051 (2016).

    Article  CAS  Google Scholar 

  15. Madden, L., Juhas, M., Kraus, W. E., Truskey, G. A. & Bursac, N. eLife 4, e04885 (2015).

    Article  Google Scholar 

  16. Takebe, T., Zhang, B. & Radisic, M. Cell Stem Cell 21, 297–300 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Helen M. Blau.

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Wang, Y.X., Blau, H.M. Macrophages rescue injured engineered muscle. Nat Biomed Eng 2, 890–891 (2018). https://doi.org/10.1038/s41551-018-0312-0

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