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Efficient siRNA delivery with non-cationic carriers

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Self-assembled weakly negative nanoparticles bearing an octet of short interfering RNAs, targeting ligands and endosomolytic peptides lead to efficient gene silencing in a mouse model of prostate cancer.

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Fig. 1: Non-cationic nanostructures for in vivo gene silencing via RNAi.

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Correspondence to Chung Hang Jonathan Choi.

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Choi, C.K.K., Zhang, L. & Choi, C.H.J. Efficient siRNA delivery with non-cationic carriers. Nat Biomed Eng 2, 275–276 (2018). https://doi.org/10.1038/s41551-018-0240-z

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