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Genetic engineering: Lassoing genomic libraries

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Long single-stranded DNA probes enable the capture and multiplexed cloning of DNA at the megabase scale.

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Figure 1: DNA libraries used in multiplexed assays.
Figure 2: Target capture via a LASSO probe.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, UCLA, Charles E. Young Drive, Los Angeles, 90095, California, USA

    Nathan B. Lubock & Sriram Kosuri

  2. UCLA-DOE Institute of Genomics and Proteomics, Charles E. Young Drive, Los Angeles, 90095, California, USA

    Nathan B. Lubock & Sriram Kosuri

  3. Molecular Biology Institute, Charles E. Young Drive, Los Angeles, 90095, California, USA

    Nathan B. Lubock & Sriram Kosuri

Authors
  1. Nathan B. Lubock
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  2. Sriram Kosuri
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Correspondence to Sriram Kosuri.

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Lubock, N., Kosuri, S. Genetic engineering: Lassoing genomic libraries. Nat Biomed Eng 1, 0098 (2017). https://doi.org/10.1038/s41551-017-0098

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