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Drug delivery: Closed-loop dynamic dosing

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A system consisting of an aptamer-based microfluidic biosensor and a simple feedback-control algorithm adjusts therapeutic dosing in near real time in small animals.

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Figure 1: Closed-loop control of drug infusion enabled by an aptamer-based microfluidic biosensor.

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  1. Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA

    Rohit Karnik

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  1. Rohit Karnik
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Correspondence to Rohit Karnik.

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Karnik, R. Drug delivery: Closed-loop dynamic dosing. Nat Biomed Eng 1, 0072 (2017). https://doi.org/10.1038/s41551-017-0072

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