Optical probes that are activated only in the tumour microenvironment dramatically improve the sensitivity of cancer detection.
References
Lutz, A. M. et al. Radiology 259, 329–345 (2011).
Lutz, A. M., Willmann, J. K., Cochran, F. V., Ray, P. & Gambhir, S. S. PLoS Med. 5, e170 (2008).
Hori, S. S. & Gambhir, S. S. Sci. Transl. Med. 3, 109ra116 (2011).
Kwon, E. J., Dudani, J. S. & Bhatia, S. N. Nat. Biomed. Eng. 1, 0054 (2017).
Zheng, X. et al. Nat. Biomed. Eng. 1, 0057 (2017).
Kwong, G. A. et al. Proc. Natl Acad. Sci. USA 112, 12627–12632 (2015).
Kwong, G. A. et al. Nat. Biotechnol. 31, 63–70 (2013).
Whitley, M. J. et al. Sci. Transl. Med. 8, 320ra324 (2016).
Ronald, J. A., Chuang, H. Y., Dragulescu-Andrasi, A., Hori, S. S. & Gambhir, S. S. Proc. Natl Acad. Sci. USA 112, 3068–3073 (2015).
Wang, Y. et al. Nat. Mater. 13, 204–212 (2014).
Jiang, T. et al. Proc. Natl Acad. Sci. USA 101, 17867–17872 (2004).
Urano, Y. et al. Nat. Med. 15, 104–109 (2009).
Zheng, X. et al. Nat. Commun. 6, 5834 (2015).
Webb, B. A., Chimenti, M., Jacobson, M. P. & Barber, D. L. Nat. Rev. Cancer 11, 671–677 (2011).
Gilkes, D. M., Semenza, G. L. & Wirtz, D. Nat. Rev. Cancer 14, 430–439 (2014).
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Hori, S., Tummers, W. & Gambhir, S. Cancer diagnostics: On-target probes for early detection. Nat Biomed Eng 1, 0062 (2017). https://doi.org/10.1038/s41551-017-0062
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DOI: https://doi.org/10.1038/s41551-017-0062
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