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Deciphering the mechanisms of gene silencing induced by triplet-repeat expansions

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A triplet repeat expansion in Arabidopsis induces gene silencing that results in a severe growth defect. We show that an interplay between a SUMO protease and histone readers of active and inactive marks is required for this gene silencing, which highlights the importance of post-translational modifiers in chromatin remodelling.

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Fig. 1: Repeat expansion-induced gene silencing requires FUG1, AL3 and LHP1.

References

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This is a summary of: Sureshkumar, S. et al. SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana. Nat. Plants https://doi.org/10.1038/s41477-024-01672-5 (2024).

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Deciphering the mechanisms of gene silencing induced by triplet-repeat expansions. Nat. Plants 10, 708–709 (2024). https://doi.org/10.1038/s41477-024-01673-4

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