Skip to main content
Log in

Coevolution of cannabinoid biosynthesis

Turning a new leaf on cannabinoids

  • News & Views
  • Published:

From Nature Plants

View current issue Submit your manuscript

Only a limited subset of angiosperms produce cannabinoids. Evidence for the independent evolution of cannabinoid biosynthesis was discovered in the South African plant Helichrysum umbraculigerum. This discovery provides an alternative set of enzymes that will expand the synthetic biology toolbox for those interested in manipulating the pathway for drug discovery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: The convergent evolution of cannabinoid biosynthesis between Cannabis sativa and Helichrysum umbraculigerum.

References

  1. Berman, P. et al. Nat. Plants https://doi.org/10.1038/s41477-023-01402-3 (2023).

    Article  PubMed  Google Scholar 

  2. Allan, G. M. et al. Can. Fam. Physician 64, e78–e94 (2018).

    PubMed  PubMed Central  Google Scholar 

  3. Nelson, K. M. et al. J. Med. Chem. 63, 12137–12155 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bohlmann, F. & Hoffmann, E. Phytochemistry 18, 1371–1374 (1979).

    Article  CAS  Google Scholar 

  5. Zhao, T. et al. Nat. Commun. 12, 3498 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Pichersky, E. & Lewinsohn, E. Annu. Rev. Plant Biol. 62, 549–566 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Stout, J. M., Boubakir, Z., Ambrose, S. J., Purves, R. W. & Page, J. E. Plant J. 71, 353–365 (2012).

    CAS  PubMed  Google Scholar 

  8. Gagne, S. J. et al. Proc. Natl Acad. Sci. USA 109, 12811–12816 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Tahir, M. N., Shahbazi, F., Rondeau-Gagné, S. & Trant, J. F. J. Cannabis Res. 3, 7 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Rizzo, P., Chavez, B. G., Leite Dias, S. & D’Auria, J. C. Curr. Opin. Biotechnol. 79, 102857 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John C. D’Auria.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chavez, B.G., D’Auria, J.C. Turning a new leaf on cannabinoids. Nat. Plants 9, 687–688 (2023). https://doi.org/10.1038/s41477-023-01415-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41477-023-01415-y

  • Springer Nature Limited

Navigation