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The revolution evolution

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Machine-learning algorithms for protein structure prediction can now generate models directly from sequences. However, photosynthetic assemblies represent a challenge due to additional levels of complexity arising from their multi-protein nature and presence of cofactors.

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Fig. 1: Evolutionary progress in structural biology of photosynthetic proteins.
Fig. 2: The structure of the PSI dimer features 614 non-protein cofactors.
Fig. 3: Structural details of cofactors in photosynthetic complexes.

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Acknowledgements

The author thanks A. Naschberger and N. Nelson for help with figures and comments, EMBO Young Investigator Program and Swedish Foundation for Strategic Research grant ARC19:0051 for support.

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  1. Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

    Alexey Amunts

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Amunts, A. The revolution evolution. Nat. Plants 8, 14–17 (2022). https://doi.org/10.1038/s41477-021-01050-5

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