Alternative splicing provides a fundamental and ubiquitous mechanism of gene regulation. Stimuli-induced retention of introns introduces novel proteoforms with altered signalling output: full-length CPK28 blocks immune signalling, while a truncated variant, lacking calcium responsiveness, promotes it.
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References
Ross, A. et al. EMBO J. 33, 62–75 (2014).
Hander, T. et al. Science 363, eaar7486 (2019).
Wang, J. et al. Mol. Cell 69, 493–504 (2018).
Monaghan, J. et al. Cell Host Microbe 16, 605–615 (2014).
Dressano, K. et al. Nat. Plants https://doi.org/10.1038/s41477-020-0724-1 (2020).
Ding, F. et al. BMC Genomics 15, 431 (2014).
Hake, K. & Romeis, T. Plant Cell Environ. 42, 904–917 (2019).
Bazin, J. et al. PLoS Pathog. 16, e1008401 (2020).
Bender, K. W. et al. J. Biol. Chem. 292, 3988–4002 (2017).
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Wirthmueller, L., Romeis, T. Sp(l)icing up PepR signalling. Nat. Plants 6, 912–913 (2020). https://doi.org/10.1038/s41477-020-0708-1
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DOI: https://doi.org/10.1038/s41477-020-0708-1
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