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PLANT IMMUNITY

A resistosome-activated ‘death switch’

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Pathogen perception triggers a monomeric nucleotide-binding leucine-rich plant immune receptor to form a pentameric wheel-like complex termed a resistosome, with the N-terminal α helices forming a funnel-shaped structure that may perturb plasma membrane integrity to cause hypersensitive cell death.

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Fig. 1: The Arabidopsis ZAR1 resistosome is proposed to directly trigger HR cell death through the formation of plasma membrane pores.

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Authors and Affiliations

  1. The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, UK

    Hiroaki Adachi, Sophien Kamoun & Abbas Maqbool

Authors
  1. Hiroaki Adachi
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  2. Sophien Kamoun
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  3. Abbas Maqbool
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Corresponding author

Correspondence to Sophien Kamoun.

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The authors declare no competing interests.

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Adachi, H., Kamoun, S. & Maqbool, A. A resistosome-activated ‘death switch’. Nat. Plants 5, 457–458 (2019). https://doi.org/10.1038/s41477-019-0425-9

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