Phosphinothricin resistance is a widely used trait in plant science research and agriculture. The BAR resistance gene that inactivates phosphinothricin has now been shown to produce two non-specific metabolites in planta. An engineered BAR resistance gene with no detectable off-target activity is developed to address this issue.
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References
Hoerlein, G. Rev. Environ. Contam. Toxicol. 138, 73–145 (1994).
Malcolm D. & Preston, C. in Herbicides and The ir Mechanisms of Action (eds Cobb, A. H. & Kirkwood, R. C.) 72–104 (CRC, Sheffield, 2000).
Botterman, J. & Leemans, J. Prospects for Amino Acid Biosynthesis Inhibitors in Crop Protection and Pharmaceutical Chemistry 63–68 (Monograph 42, BCPC, 1989).
Christ, B. et al. Nat. Plants http://doi.org/10.1038/s41477-017-0061-1 (2017).
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O’Connor, S.E. Raising the BAR of specificity. Nature Plants 3, 924–925 (2017). https://doi.org/10.1038/s41477-017-0074-9
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DOI: https://doi.org/10.1038/s41477-017-0074-9
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