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A facile preparation and crystal structure of romipeptide A

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Abstract

A double disulfide tethering depsipeptide dimer, romipeptide A (1) was prepared by NaOH catalyzed dimerization of romidepsin. Its structure was determined by analysis of NMR and HR-ESI-MS data as well as single crystal X-ray diffraction. Bioassay results showed that 1 exhibited good cytotoxic activity against two tumor cell lines B16 and HCT116. This study reported the single crystal data of 1 for the first time. The facile preparation of 1 afforded enough amount for its further biological evaluations.

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Acknowledgements

This research was financially supported by the Key Research and Development Program of Zhejiang Province (Grant No: 2020C02028) and Taizhou Science and Technology Plan Project (21nya24).

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Correspondence to Ji-dong Wang or Wen-sheng Xiang.

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Zhang, H., Qi, H., Duan, Wk. et al. A facile preparation and crystal structure of romipeptide A. J Antibiot 75, 48–50 (2022). https://doi.org/10.1038/s41429-021-00487-2

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