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A concise total synthesis and PPAR activation activity of hericerin from Hericium erinaceum

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Abstract

Hericerin is an isoindolinone meroterpenoid alkaloid isolated from medicinal mushroom Hericium erinaceum with some bioactivities. Herein, a concise total synthesis of hericerin was described, with four steps and 30% overall yield starting from commercially available methyl 3-hydroxy-5-methoxybenzoate and geranyl bromide. A comprehensive effect of hericerin on HepG2 cell line was observed and confirmed by transcriptomic analysis. Furthermore, hericerin was found to be a new PPARγ agonist.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (21472233 and 21877124).

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Authors and Affiliations

  1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, 100101, Beijing, PR China

    Zhongyong Zheng, Baosong Chen, Li Bao & Hongwei Liu

  2. Savaid Medical School, University of Chinese Academy of Sciences, 100049, Beijing, PR China

    Zhongyong Zheng, Baosong Chen, Li Bao & Hongwei Liu

  3. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, 100191, Beijing, PR China

    Kai Wang

  4. Department of chemistry, Capital Normal University, 100048, Beijing, PR China

    Zhengdi Wang, Liping Xie & Changbin Guo

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  1. Zhongyong Zheng
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  2. Baosong Chen
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  3. Kai Wang
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  4. Li Bao
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  5. Zhengdi Wang
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  6. Liping Xie
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  7. Changbin Guo
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  8. Hongwei Liu
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Correspondence to Hongwei Liu.

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Zheng, Z., Chen, B., Wang, K. et al. A concise total synthesis and PPAR activation activity of hericerin from Hericium erinaceum. J Antibiot 73, 646–649 (2020). https://doi.org/10.1038/s41429-020-0303-8

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  • DOI: https://doi.org/10.1038/s41429-020-0303-8

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