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Trained immunity and macrophage reprogramming in allergic disorders

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References

  1. Chen PC, Shao YT, Hsieh MH, Kao HF, Kuo WS, Wang SM, et al. Early-life EV-A71 infection augments allergen-induced airway inflammation in asthma through trained immunity of macrophages. Cell Mol Immunol. 2021;18:472–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Netea MG, Quintin J, van der Meer JW. Trained immunity: a memory for innate host defense. Cell Host Microbe. 2011;9:355–61.

    Article  CAS  PubMed  Google Scholar 

  3. Wu LSH, Wang JY. Warm up, cool down, and tearing apart in NK cell memory. Cell Mol Immunol. 2018;15:1095–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Naik S, Larsen SB, Gomez NC, Alaverdyan K, Sendoel A, Yuan S, et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature. 2017;550:475–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Chavakis T, Mitroulis I, Hajishengallis G. Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation. Nat Immunol. 2019;20:802–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Fanucchi S, Dominguez-Andres J, Joosten LAB, Netea MG, Mhlanga MM. The intersection of epigenetics and metabolism in trained immunity. Immunity. 2021;54:32–43.

    Article  CAS  PubMed  Google Scholar 

  7. Dominguez-Andres J, Fanucchi S, Joosten LAB, Mhlanga MM, Netea MG. Advances in understanding molecular regulation of innate immune memory. Curr Opin Cell Biol. 2020;63:68–75.

    Article  CAS  PubMed  Google Scholar 

  8. Domínguez-Andrés J, Dos Santos JC, Bekkering S, Mulder WJM, van der Meer JWM, Riksen NP, et al. Trained immunity: adaptation within innate immune mechanisms. Physiol Rev. 2023;103:313–46.

    Article  PubMed  Google Scholar 

  9. Wang JY. The innate immune response in house dust mite-induced allergic inflammation. Allergy Asthma Immunol Res. 2013;5:68–74.

    Article  CAS  PubMed  Google Scholar 

  10. Neeland MR, Novakovic B, Dang TD, Perrett KP, Koplin JJ, Saffery R. Hyper-inflammatory monocyte activation following endotoxin exposure in food allergic infants. Front Immunol. 2020;11:567981.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Rajput C, Han M, Ishikawa T, Lei J, Jazaeri S, Bentley JK, et al. Early-life heterologous rhinovirus infections induce an exaggerated asthma-like phenotype. J Allergy Clin Immunol. 2020;146:571–82.e3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Zubair K, You C, Kwon G, Kang K. Two faces of macrophages: training and tolerance. Biomedicines. 2021;9:1596.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Chen KR, Ling P. Interplays between Enterovirus A71 and the innate immune system. J Biomed Sci. 2019;26:95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Benito-Villalvilla C, Perez-Diego M, Angelina A, Kisand K, Rebane A, Subiza JL, et al. Allergoid-mannan conjugates reprogram monocytes into tolerogenic dendritic cells via epigenetic and metabolic rewiring. J Allergy Clin Immunol. 2022;149:212–22.e9.

    Article  CAS  PubMed  Google Scholar 

  15. Chen PC, Hsieh MH, Kuo WS, Wu LS, Kao HF, Liu LF, et al. Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages. J Biomed Sci. 2022;29:75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Center for Allergy, Immunology, and Microbiome (A.I.M.), China Medical University Hospital, Taichung, Taiwan, China

    Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo & Jiu-Yao Wang

  2. Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan, China

    Pei-Chi Chen

  3. School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, China

    Wen-Shuo Kuo

  4. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, China

    Lawrence Shih-Hsin Wu

  5. Department of Allergy, Immunology, and Rheumatology (AIR), China Medical University Children’s Hospital, Taichung, Taiwan, China

    Jiu-Yao Wang

Authors
  1. Pei-Chi Chen
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  2. Miao-Hsi Hsieh
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  3. Wen-Shuo Kuo
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  4. Lawrence Shih-Hsin Wu
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  5. Jiu-Yao Wang
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Contributions

PCC and JYW conceived and designed the first draft. MHH, WSK, and LSHW made the references check. PCC drew the figure. All authors read and approved the fnal manuscript.

Corresponding author

Correspondence to Jiu-Yao Wang.

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The authors declare no competing interests.

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Chen, PC., Hsieh, MH., Kuo, WS. et al. Trained immunity and macrophage reprogramming in allergic disorders. Cell Mol Immunol 20, 1084–1086 (2023). https://doi.org/10.1038/s41423-023-01005-0

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