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Immunopathogenesis of idiopathic nephrotic syndrome

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References

  1. Lane BM, Cason R, Esezobor CI, Gbadegesin RA. Genetics of childhood steroid sensitive nephrotic syndrome: an update. Front Pediatr. 2019;7:8.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Frank C, Herrmann M, Fernandez S, Dirnecker D, Boswald M, Kolowos W, et al. Dominant T cells in idiopathic nephrotic syndrome of childhood. Kidney Int. 2000;57:510–7.

    Article  CAS  PubMed  Google Scholar 

  3. Boumediene A, Vachin P, Sendeyo K, Oniszczuk J, Zhang SY, Henique C, et al. NEPHRUTIX: a randomized, double-blind, placebo vs Rituximab-controlled trial assessing T-cell subset changes in Minimal Change Nephrotic Syndrome. J Autoimmun. 2018;88:91–102.

    Article  CAS  PubMed  Google Scholar 

  4. Liu LL, Qin Y, Cai JF, Wang HY, Tao JL, Li H, et al. Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome. Clin Immunol. 2011;139:314–20.

    Article  CAS  PubMed  Google Scholar 

  5. Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood. 2006;107:3925–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Colucci M, Carsetti R, Cascioli S, Casiraghi F, Perna A, Rava L, et al. B cell reconstitution after rituximab treatment in idiopathic nephrotic syndrome. J Am Soc Nephrol. 2016;27:1811–22.

    Article  CAS  PubMed  Google Scholar 

  7. Kemper MJ, Altrogge H, Ganschow R, Muller-Wiefel DE. Serum levels of immunoglobulins and IgG subclasses in steroid sensitive nephrotic syndrome. Pediatr Nephrol. 2002;17:413–7.

    Article  PubMed  Google Scholar 

  8. Yang X, Tang X, Li T, Man C, Yang X, Wang M, et al. Circulating follicular T helper cells are possibly associated with low levels of serum immunoglobulin G due to impaired immunoglobulin class-switch recombination of B cells in children with primary nephrotic syndrome. Mol Immunol. 2019;114:162–70.

    Article  CAS  PubMed  Google Scholar 

  9. Chan CY, Liu ID, Resontoc LP, Ng KH, Chan YH, Lau PY, et al. T lymphocyte activation markers as predictors of responsiveness to rituximab among patients with FSGS. Clin J Am Soc Nephrol. 2016;11:1360–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wallin EF, Jolly EC, Suchanek O, Bradley JA, Espeli M, Jayne DR, et al. Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers. Blood. 2014;124:2666–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Zabel F, Fettelschoss A, Vogel M, Johansen P, Kundig TM, Bachmann MF. Distinct T helper cell dependence of memory B-cell proliferation versus plasma cell differentiation. Immunology. 2017;150:329–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Rood IM, Huussen J, Wetzels JF, Deegens JK. Rituximab can induce remission of nephrotic syndrome in the absence of peripheral B-cells. Nephrology. 2015;20:667–8.

    Article  PubMed  Google Scholar 

  13. Oniszczuk J, Sendeyo K, Chhuon C, Savas B, Cogne E, Vachin P, et al. CMIP is a negative regulator of T cell signaling. Cell Mol Immunol. 2020;17:1026–41.

    Article  CAS  PubMed  Google Scholar 

  14. Audard V, Zhang SY, Copie-Bergman C, Rucker-Martin C, Ory V, Candelier M, et al. Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes. Blood. 2010;115:3756–62.

    Article  CAS  PubMed  Google Scholar 

  15. Zhang SY, Kamal M, Dahan K, Pawlak A, Ory V, Desvaux D, et al. c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci Signal. 2010;3:ra39.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Université Paris Est (UPEC), Faculté de Santé, UMRS 955, Créteil, F-94010, France

    B. Savas, F. Fofana, S. Le Gouvello, A. Pawlak, D. Sahali & M. Ollero

  2. AP-HP, Groupe Henri-Mondor Albert-Chenevier, Service de Néphrologie, Créteil, F-94010, France

    D. Sahali

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  1. B. Savas
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  2. F. Fofana
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  3. S. Le Gouvello
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  4. A. Pawlak
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  5. D. Sahali
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  6. M. Ollero
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Correspondence to D. Sahali.

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Savas, B., Fofana, F., Le Gouvello, S. et al. Immunopathogenesis of idiopathic nephrotic syndrome. Cell Mol Immunol 19, 1429–1431 (2022). https://doi.org/10.1038/s41423-022-00908-8

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  • DOI: https://doi.org/10.1038/s41423-022-00908-8

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