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The homeostatic γc cytokines IL-7 and IL-15 suppress the induction of CD4+CD8αα+ intraepithelial T cells in the gut

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References

  1. Singer A, Adoro S, Park JH. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol. 2008;8:788–801.

    Article  CAS  Google Scholar 

  2. Moon S, Park Y, Hyeon S, Kim YM, Kim JH, Kim H, et al. Niche-specific MHC II and PD-L1 regulate CD4+CD8alphaalpha+ intraepithelial lymphocyte differentiation. J Exp Med. 2021;218:1516.

    Article  Google Scholar 

  3. Reis BS, Rogoz A, Costa-Pinto FA, Taniuchi I, Mucida D. Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4(+) T cell immunity. Nat Immunol. 2013;14:271–80.

    Article  CAS  Google Scholar 

  4. Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, et al. Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol. 2013;14:281–9.

    Article  CAS  Google Scholar 

  5. Olivares-Villagomez D, Van Kaer L. Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier. Trends Immunol. 2018;39:264–75.

    Article  CAS  Google Scholar 

  6. Van Kaer L, Algood H, Singh K, Parekh VV, Greer MJ, Piazuelo MB, et al. CD8alphaalpha(+) innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity 2014;41:451–64.

    Article  Google Scholar 

  7. Zhou C, Qiu Y, Yang H. CD4CD8alphaalpha IELs: They Have Something to Say. Front Immunol. 2019;10:2269.

    Article  CAS  Google Scholar 

  8. Klose CSN, Blatz K, d’Hargues Y, Hernandez PP, Kofoed-Nielsen M, Ripka JF, et al. The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development. Immunity 2014;41:230–43.

    Article  CAS  Google Scholar 

  9. Waickman AT, Park JY, Park JH. The common gamma-chain cytokine receptor: tricks-and-treats for T cells. Cell Mol Life Sci. 2016;73:253–69.

    Article  CAS  Google Scholar 

  10. Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity 2014;41:244–56.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the Intramural Research Program of the US National Institutes of Health, National Cancer Institute, Center for Cancer Research.

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Authors and Affiliations

  1. Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Can Li, Praveen Prakhar & Jung-Hyun Park

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  1. Can Li
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  2. Praveen Prakhar
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  3. Jung-Hyun Park
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Contributions

CL performed experiments, analyzed data, and wrote the paper. PP performed experiments and analyzed data. JHP directed the study and wrote the paper.

Corresponding author

Correspondence to Jung-Hyun Park.

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The authors declare no competing interests.

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Li, C., Prakhar, P. & Park, JH. The homeostatic γc cytokines IL-7 and IL-15 suppress the induction of CD4+CD8αα+ intraepithelial T cells in the gut. Cell Mol Immunol 19, 751–753 (2022). https://doi.org/10.1038/s41423-022-00868-z

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