Skip to main content
SpringerLink
Log in

The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells

  • Research Highlight
  • Published:
Cellular & Molecular Immunology Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Weisel, F. J. & Shlomchik, M. J. Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis. Nat. Immunol. 21, 331–342 (2020).

    Article  CAS  Google Scholar 

  2. Lunt, S. Y. & Vander Heiden, M. G. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 27, 441–464 (2011).

    Article  CAS  Google Scholar 

  3. Jellusova, J. et al. Gsk3 is a metabolic checkpoint regulator in B cells. Nat. Immunol. 18, 303–312 (2017).

    Article  CAS  Google Scholar 

  4. Waters, L. R., Ahsan, F. M., Wolf, D. M., Shirihai, O. & Teitell, M. A. Initial B Cell activation induces metabolic reprogramming and mitochondrial remodeling. iScience 5, 99–109 (2018).

    Article  CAS  Google Scholar 

  5. Chang, C. H. et al. XPosttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239 (2013).

    Article  CAS  Google Scholar 

  6. Ecker, C. et al. Differential Reliance on lipid metabolism as a salvage pathway underlies functional differences of t cell subsets in poor nutrient environments. Cell Rep. 23, 741–755 (2018).

    Article  CAS  Google Scholar 

  7. Howie, D., et al. The role of lipid metabolism in T lymphocyte differentiation and survival. Front. Immunol. 8, 1949 (2018).

    Article  Google Scholar 

  8. Wheeler, M. L. & DeFranco, A. L. Prolonged production of reactive oxygen species in response to b cell receptor stimulation promotes b cell activation and proliferation. J. Immunol. 189, 4405–4416 (2012).

    Article  CAS  Google Scholar 

  9. Diggins, K., Huse, J. M., Irish, H. G., Polikowsky, C. E. & Wogsland, K. E. Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells. J. Immunol.195, 1364-1367 (2015).

    Article  Google Scholar 

  10. Quijano, C., Trujillo, M., Castro, L. & Trostchansky, A. Interplay between oxidant species and energy metabolism. Redox Biol. 8, 28–42 (2016).

    Article  CAS  Google Scholar 

  11. Basso, K. & Dalla-Favera, R. Roles of BCL6 in normal and transformed germinal center B cells. Immunol. Rev. 247, 172–183 (2012).

    Article  Google Scholar 

  12. Ricciardi, M. R. et al. Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias. Blood 126, 1925–1929 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge funding support by the European Research Council (Consolidator Grant 724281 to A.B.v.S.) and Sjoerd van Deventer and Vera Dunlock for critically reading the manuscript. The authors have no competing interest.

Author information

Authors and Affiliations

  1. Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands

    Rens Peeters & Annemiek B. van Spriel

Authors
  1. Rens Peeters
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Annemiek B. van Spriel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Annemiek B. van Spriel.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Peeters, R., van Spriel, A.B. The fat and the furious: fatty acids fuel hyperproliferative germinal center B cells. Cell Mol Immunol 17, 794–796 (2020). https://doi.org/10.1038/s41423-020-0446-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41423-020-0446-3

  • Springer Nature Limited

This article is cited by

Search

Navigation