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Interleukin 7 regulates switch transcription in developing B cells

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References

  1. Yu, K. & Lieber, M. R. Current insights into the mechanism of mammalian immunoglobulin class switch recombination. Crit. Rev. Biochem. Mol. Biol. 54, 333–351 (2019).

    Article  CAS  Google Scholar 

  2. Han, J. H. et al. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 27, 64–75 (2007).

    Article  CAS  Google Scholar 

  3. Edry, E., Azulay-Debby, H. & Melamed, D. TOLL-like receptor ligands stimulate aberrant class switch recombination in early B cell precursors. Int. Immunol. 20, 1575–1585 (2008).

    Article  CAS  Google Scholar 

  4. Swaminathan, S. et al. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat. Immunol. 16, 766–774 (2015).

    Article  CAS  Google Scholar 

  5. Braikia, F. Z. et al. Inducible CTCF insulator delays the IgH 3’ regulatory region-mediated activation of germline promoters and alters class switching. Proc. Natl Acad. Sci. USA 114, 6092–6097 (2017).

    Article  CAS  Google Scholar 

  6. Ceredig, R. & Rolink, A. G. The key role of IL-7 in lymphopoiesis. Semin. Immunol. 24, 159–164 (2012).

    Article  CAS  Google Scholar 

  7. Clark, M. R., Mandal, M., Ochiai, K. & Singh, H. Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling. Nat. Rev. Immunol. 14, 69–80 (2014).

    Article  CAS  Google Scholar 

  8. Corcoran, A. E. et al. The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J. 15, 1924–1932 (1996).

    Article  CAS  Google Scholar 

  9. Chowdhury, D. & Sen, R. Transient IL-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity 18, 229–241 (2003).

    Article  CAS  Google Scholar 

  10. Malin, S. et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat. Immunol. 11, 171–179 (2010).

    Article  CAS  Google Scholar 

  11. Heltemes-Harris, L. M. & Farrar, M. A. The role of STAT5 in lymphocyte development and transformation. Curr. Opin. Immunol. 24, 146–152 (2012).

    Article  CAS  Google Scholar 

  12. Dooms, H. Interleukin-7: fuel for the autoimmune attack. J. Autoimmun. 45, 40–48 (2013).

    Article  CAS  Google Scholar 

  13. Peschon, J. J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955–1960 (1994).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Amy L. Kenter and Cornelis Murre for their help with the RAG-deficient pro-B cell cultures and the IPBS animal facility staff and the Imaging Core Facility TRI-IPBS, in particular Emmanuelle Näser, for their excellent work. This work was supported by the Agence Nationale de la Recherche (ANR-16-CE12-0017), the Institut National du Cancer (INCA_9363, PLBIO15-134), the Fondation ARC pour la Recherche sur le Cancer (PJA 20191209515), and the Ligue Contre le Cancer (Ligue Régionale: Comités de l’Ex Région Midi-Pyrénées). F.-Z.B. was supported by a fellowship from the INCa. C.O. is a fellow of the Ministry of Higher Education & Research and is the recipient of a fellowship from the Fondation pour la Recherche Médicale. Tri-IPBS has financial support from ITMO Cancer Aviesan (the National Alliance for Life Science and Health) within the framework of the Cancer Plan.

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Authors and Affiliations

  1. Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, Université Paul Sabatier, 31077, Toulouse, France

    Audrey Dauba, Fatima-Zohra Braikia, Chloé Oudinet & Ahmed Amine Khamlichi

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  1. Audrey Dauba
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  2. Fatima-Zohra Braikia
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  3. Chloé Oudinet
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  4. Ahmed Amine Khamlichi
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Contributions

Conceptualization: A.A.K. Methodology: A.D., F.-Z.B., C.O., and A.A.K. Investigation: A.D., F.-Z.B., and C.O. Handling of mouse lines: A.D. Writing—original draft: A.A.K. Writing—review and editing: A.D., F.-Z.B., C.O., and A.A.K. Supervision: A.A.K. Funding acquisition: A.A.K.

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Correspondence to Ahmed Amine Khamlichi.

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Dauba, A., Braikia, FZ., Oudinet, C. et al. Interleukin 7 regulates switch transcription in developing B cells. Cell Mol Immunol 18, 776–778 (2021). https://doi.org/10.1038/s41423-020-0430-y

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