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The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer

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Acknowledgements

This research is supported by grants from the National Natural Science Foundation for Key Programs of China (31730024, G.L.), the National Natural Science Foundation for General Programs of China (31671524, G.L.), and the Beijing Municipal Natural Science Foundation of China (5202013, GL).

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Author notes

  1. These authors contributed equally: Anna Jia, Yuexin Wang, Yufei Wang, Yan Li

Authors and Affiliations

  1. Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, 100875, China

    Anna Jia, Yuexin Wang, Yufei Wang, Yan Li, Qiuli Yang, Yejin Cao, Ying He, Lin Dong, Yingjie Dong, Yueru Hou & Guangwei Liu

  2. Center for Childhood Cancer & Blood Diseases, The Research Institute at Nationwide Children’s Hospital, Ohio State University, Columbus, OH, 43205, USA

    Ruoning Wang

  3. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China

    Yujing Bi

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  1. Anna Jia
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  2. Yuexin Wang
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Contributions

A.J., Y.B., and Y.X.W. designed and conducted the mouse and cell experiment and analyzed the data; Y.F.W., Y.L., Q.Y. Y.C., Y.H., L.D., Y.D., Y.H., and R.W. participated in discussions; R.W. and Y.B. contributed to writing the manuscript; and G.L. developed the concept, designed and conducted the experiments, analyzed the data, wrote the manuscript, and provided overall direction.

Corresponding authors

Correspondence to Ruoning Wang, Yujing Bi or Guangwei Liu.

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Competing interests

The authors declare no competing interests.

Ethics approval and consent to participate

The present study was approved by the Ethics Committee of the College of Life Science of Beijing Normal University, Beijing China.

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Jia, A., Wang, Y., Wang, Y. et al. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol 18, 1074–1076 (2021). https://doi.org/10.1038/s41423-020-00610-7

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  • DOI: https://doi.org/10.1038/s41423-020-00610-7

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