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CCRK—a hub for liver metastasis and cancer

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References

  1. Golubnitschaja, O. & Sridhar, K. C. Liver metastatic disease: new concepts and biomarker panels to improve individual outcomes. Clin. Exp. Metastasis 33, 743–755 (2016).

    Article  CAS  Google Scholar 

  2. Agarwala, S. S., Eggermont, A. M., O’Day, S. & Zager, J. S. Metastatic melanoma to the liver: a contemporary and comprehensive review of surgical, systemic, and regional therapeutic options. Cancer 120, 781–789 (2014).

    Article  Google Scholar 

  3. Valderrama-Trevino, A. I., Barrera-Mera, B., Ceballos-Villalva, J. C. & Montalvo-Jave, E. E. Hepatic metastasis from colorectal cancer. Euroasian J. Hepatogastroenterol 7, 166–175 (2017).

    Article  Google Scholar 

  4. Zeng, X. et al. Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis. Cell Mol. Immunol. https://doi.org/10.1038/s41423-020-00534-2 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lee, J. W. et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature 567, 249–252 (2019).

    Article  CAS  Google Scholar 

  6. Feng, H. et al. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis. J. Clin. Invest 121, 3159–3175 (2011).

    Article  CAS  Google Scholar 

  7. Yu, Z. et al. Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis. Gut 63, 1793–1804 (2014).

    Article  CAS  Google Scholar 

  8. Feng, H. et al. A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. J. Hepatol. 62, 1100–1111 (2015).

    Article  CAS  Google Scholar 

  9. Mok, M. T. et al. CCRK is a novel signalling hub exploitable in cancer immunotherapy. Pharm. Ther. 186, 138–151 (2018).

    Article  CAS  Google Scholar 

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Acknowledgements

This study was supported by a grant from the Ministry of Science and Technology (MOST 108-2314-B-194-003-MY2).

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Correspondence to Michael W. Y. Chan.

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Low, JT., Lin, GL. & Chan, M.W.Y. CCRK—a hub for liver metastasis and cancer. Cell Mol Immunol 18, 1341–1342 (2021). https://doi.org/10.1038/s41423-020-00569-5

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  • DOI: https://doi.org/10.1038/s41423-020-00569-5

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